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KMID : 0191119990140060671
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Journal of Korean Medical Science
1999 Volume.14 No. 6 p.671 ~ p.674
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Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report
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Kwon SY
Lee JJ/Chung IJ/Kim HJ/Park MR/Kim HS/Park CS
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Abstract
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While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
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KEYWORD
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